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connective tissue growth factor gene therapy


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Connective Tissue Growth Factor Antibody Therapy ...- connective tissue growth factor gene therapy ,Connective tissue growth factor (CTGF) is a matricellular protein that plays an important role in tissue development and remodeling. Previous studies have demonstrated that hyperoxia exposure up-regulates CTGF expression in neonatal rat lungs.A physiological role for connective tissue growth factor ...Igarashi A, Nashiro K, Kikuchi K, et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol. 1996; 106:729–733. [Google Scholar]



Connective tissue growth factor expression and Smad ...

Sep 16, 2004·INTRODUCTION. Connective tissue growth factor (CTGF) was first isolated from human umbilical vein endothelial cells (Bradham et al., 1991).This secreted growth factor belongs to the CCN family, which includes CYR61 and NOV (Brigstock, 2003).CTGF binds to extracellular matrix proteins (ECM) and integrins (Moussad and Brigstock, 2000), but also to …

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Pathogenic Role of Connective Tissue Growth Factor (CTGF ...

Dec 04, 2009·Introduction: Connective tissue growth factor (CTGF/CCN2) is a mediator of local angiogenesis induced by breast cancer, but its role in osteolytic metastasis has not been evaluated. PTH-related peptide (PTHrP) is another critical factor in the development of the osteolytic metastasis.

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Connective tissue growth factor autocriny in human ...

Dec 02, 2011·Connective tissue growth factor (CTGF) is a cysteine-rich secreted protein that interacts with a variety of extracellular matrix components and cell-surface proteins, such as fibronectin, proteoglycans, and integrins, strongly influencing cellular behavior. 4 CTGF participates in many biological processes, including cell proliferation, survival ...

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CTGF is a central mediator of tissue remodeling and ...

Jun 06, 2012·CTGF and its modulation of cell biology. Connective tissue growth factor (CTGF, CCN2) is a member of a small family of proteins that are characterized by their highly conserved disulfide bonding pattern and having 3-4 domains with homology to other proteins [1, 2].CTGF has four domains: domain 1 is homologous to IGF-1 binding proteins, domain 2 is …

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Academia.edu - Share research

Connective tissue growth factor level is increased in patients with liver cirrhosis but is not associated with complications or extent of liver injury Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model

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Connective tissue growth factor promotes articular damage ...

Nov 18, 2009·A protein analysis using a mass spectrometry indicated that there are serum proteins showing significant quantitative changes after the administration of infliximab. Among them, connective tissue growth factor (CTGF) seems to be related to the pathogenesis of rheumatoid arthritis (RA). Therefore, this study was conducted to investigate how CTGF is …

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CTGF - Connective tissue growth factor - Homo sapiens ...

May 10, 2005·Connective tissue growth factor. Gene. CTGF. Organism. Homo sapiens (Human) Status. Unreviewed-Annotation score: -Experimental evidence at transcript level i. Function i Caution. Lacks conserved residue(s) required for the propagation of feature annotation. ...

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Convergent signaling in the regulation of connective ...

therapy for MM is urgently required. Our recent studies suggest that nor-mal mesothelial and MM cell growth is promoted by TGFβ, and that TGFβ signaling together with intrinsic dis-turbances in neurofibromatosis type 2 (NF2) and Hippo signaling cascades in MM cells converges upon further expression of connective tissue growth factor (CTGF).

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Regulation of connective tissue growth factor gene ...

Oct 13, 2017·Connective tissue growth factor (CTGF) is a cysteine-rich peptide that exhibits platelet-derived growth factor (PDGF)-like biological and immunological activities. CTGF is a member of a family of peptides that include serum-induced immediate early gene products, a v-src-induced peptide, and a putative avian transforming gene, nov.

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Academia.edu - Share research

Connective tissue growth factor level is increased in patients with liver cirrhosis but is not associated with complications or extent of liver injury Connective tissue growth factor/CCN-2 is upregulated in epididymal and subcutaneous fat depots in a dietary-induced obesity model

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Role of connective tissue growth factor in fibronectin ...

May 01, 2002·Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int 58 2000 13891399 Crossref | PubMed | ISI Google Scholar; 23 Hishikawa K, Oemar BS, Tanner FC, Nakaki T, Fujii T, Luscher TF. Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells.

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Connective Tissue Breakdown: Remodeling, Repair, and ...

Oct 25, 2019·Dilated blood vessels carry white blood cells to the damaged areas. The release of interleukins and Transforming Growth Factor Beta (TGFβ), a hormonally active polypeptide, stimulate Connective Tissue Growth Factor (CTGF) and other polypeptide growth factors, which promote cell growth, adhesion, migration and angiogenesis [17,18].

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Targeting CTGF in Cancer: An Emerging Therapeutic ...

Despite the dramatic advances in cancer research over the decades, effective therapeutic strategies are still urgently needed. Increasing evidence indicates that connective tissue growth factor (CTGF), a multifunctional signaling modulator, promotes cancer initiation, progression, and metastasis by regulating cell proliferation, migration, invasion, drug resistance, and epithelial ...

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Regulation of connective tissue growth factor (CTGF/CCN2 ...

Nov 02, 2004·Connective tissue growth factor (CTGF) also known as CCN2 was identified as an immediate early responsive gene activated by growth factors in connective tissue cell types [[1, 2]].It encodes 349 amino acids of which the first 26 residues are a presumptive signal peptide for secretion of the protein, which belongs to a family of extracellular matrix-associated, …

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Pamrevlumab, an anti-connective tissue growth factor ...

Sep 28, 2019·Connective tissue growth factor (CTGF) is a secreted glycoprotein that has a central role in the process of fibrosis. This study was designed to assess the safety, tolerability, and efficacy of pamrevlumab (FG-3019), a fully recombinant human monoclonal antibody against CTGF, in idiopathic pulmonary fibrosis.

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Connective tissue growth factor promoter activity in ...

Oct 13, 2008·In skin, connective tissue growth factor (CTGF/CCN2) is induced during tissue repair. However, what the exact cell types are that express CTGF in normal and wounded skin remain controversial. In this report, we use transgenic knock-in mice in which the Pacific jellyfish Aequorea victoria enhanced green fluorescent protein (E-GFP) gene has been inserted …

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Pamrevlumab, an anti-connective tissue growth factor ...

Sep 28, 2019·Connective tissue growth factor (CTGF) is a secreted glycoprotein that has a central role in the process of fibrosis. This study was designed to assess the safety, tolerability, and efficacy of pamrevlumab (FG-3019), a fully recombinant human monoclonal antibody against CTGF, in idiopathic pulmonary fibrosis.

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Overexpression of Connective Tissue Growth Factor …

Nov 16, 1999·Connective tissue growth factor (CTGF) is a cysteine-rich peptide that was originally identified as a growth factor secreted by endothelial cells. 1 CTGF is mitogenic to NRK cells 2 and chemotactic to NIH 3T3 cells. 2 …

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Connective Tissue Growth Factor Antibody Therapy ...

Connective tissue growth factor (CTGF) is a matricellular protein that plays a critical role in the pathogenesis of various forms of adult pulmonary fibrosis and vascular disease (10–13). Indeed, anti-CTGF therapy with neutralizing CTGF monoclonal …

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Regulation of connective tissue growth factor gene ...

Oct 13, 2017·Connective tissue growth factor (CTGF) is a cysteine-rich peptide that exhibits platelet-derived growth factor (PDGF)-like biological and immunological activities. CTGF is a member of a family of peptides that include serum-induced immediate early gene products, a v-src-induced peptide, and a putative avian transforming gene, nov.

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Connective Tissue Growth Factor - an overview ...

Connective Tissue Growth Factor (CTGF) CTGF is considered to be profibrotic by a mechanism related to TGF-β. CTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates …

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Regulation of connective tissue growth factor (CTGF/CCN2 ...

Nov 02, 2004·Connective tissue growth factor (CTGF) also known as CCN2 was identified as an immediate early responsive gene activated by growth factors in connective tissue cell types [[1, 2]].It encodes 349 amino acids of which the first 26 residues are a presumptive signal peptide for secretion of the protein, which belongs to a family of extracellular matrix-associated, …

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Gene regulation of connective tissue growth factor: new ...

CTGF is an interesting target for future antifibrotic therapies as it is conceivable that inhibition of CTGF might block the profibrotic effects of TGFbeta, without affecting TGFbeta's anti-proliferative and immunosuppressive effects.

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Frontiers | Gene Therapy Using Plasmid DNA Encoding ...

Oct 10, 2017·Gene Therapy Using Plasmid DNA Encoding Vascular Endothelial Growth Factor 164 and Fibroblast Growth Factor 2 Genes for the Treatment of Horse Tendinitis and Desmitis: Case Reports Milomir Kovac 1 *, Yaroslav A. Litvin 2 , Ruslan O. Aliev 1 , Elena Yu Zakirova 2 , Catrin S. Rutland 3 , Andrey P. Kiyasov 2 and Albert A. Rizvanov 2 *

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